Abstract

GODINEZ MARTINEZ, Estela Ytelina et al. Determination of 2-hydroxyestrone/16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors. Nutr. Hosp. [online]. 2015, vol.31, n.2, pp.835-840. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.31.2.8172.

The urinary ratio 2-hydroxyoestrone/16α-hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined. Objective: To determine URME Mexican women and establish its relationship with risk factors for BC. Material and Methods: Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMET^TM and was related to risk factors for BC. Correlations and linear regressions were performed. Results: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p<0.000). IMC participated in 6.1% of the variability of 2-hydroxyoes-trone in premenopausal (F=4.40; p<0.000) and 18.1% in posmenopausal women (F=8.85; p<0.000). Conclusion: The URME was ≈50% lower than reported for other populations and inversely proportional to BMI.

Keywords : 2-hydroxyoestrone; 16α-hydroxyoestrone; Breast cancer; Body mass index and early menarche.

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