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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611


GODINEZ MARTINEZ, Estela Ytelina et al. Determination of 2-hydroxyestrone/16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors. Nutr. Hosp. [online]. 2015, vol.31, n.2, pp.835-840. ISSN 1699-5198.

The urinary ratio 2-hydroxyoestrone/16α-hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined. Objective: To determine URME Mexican women and establish its relationship with risk factors for BC. Material and Methods: Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMETTM and was related to risk factors for BC. Correlations and linear regressions were performed. Results: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p<0.000). IMC participated in 6.1% of the variability of 2-hydroxyoes-trone in premenopausal (F=4.40; p<0.000) and 18.1% in posmenopausal women (F=8.85; p<0.000). Conclusion: The URME was ≈50% lower than reported for other populations and inversely proportional to BMI.

Keywords : 2-hydroxyoestrone; 16α-hydroxyoestrone; Breast cancer; Body mass index and early menarche.

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