Abstract

ALBUQUERQUE, Mellina Neyla de Lima; DINIZ, Alcides da Silva  and  ARRUDA, Ilma Kruze Grande de. Apolipoproteins and their association with cardiometabolic risk biomarkers in adolescents. Nutr. Hosp. [online]. 2015, vol.32, n.6, pp.2674-2683. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.6.9779.

Introduction: the apoB/apo A-I ratio has been reported as an important predictor of cardiovascular risk, being superior to lipids, lipoproteins and conventional lipid ratios. Objective: to investigate the association between apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and cardiometabolic risk variables in adolescents. Methods: this was a cross-sectional study including 104 adolescents of public schools in Recife during the months of March/April, 2013. Sociodemographic, anthropometric, clinical and biochemical variables were analysed. The apolipoproteins were analysed via Immunoturbidimetry. Results: body mass index, waist circumference, waist circumference/height, triglycerides, cholesterol/HDL, and apolipoprotein B/apolipoprotein A-I declined with the progress of the percentile distribution of apolipoprotein A-I concentrations, while the HDL and apolipoprotein B increased between the first and last quartiles of the apolipoprotein A-I concentrations. Systolic blood pressure, body mass index, waist circumference, waist circumference/height, cholesterol, LDL, triglycerides, cholesterol/HDL, and LDL/HDL increased progressively in the quartile distribution of the concentrations of apolipoprotein B and apolipoprotein B/apolipoprotein A-I. Alfa-1-acid glycoprotein serum levels increased hand-inhand with the percentile progression of apolipoprotein B. Conclusions: the findings underline an important association of apolipoproteins A-I and B, and the apolipoprotein B/apolipoprotein A-I ratio and their clinical, biochemical and anthropometric cardiometabolic risk. However, prospective studies are important to evaluate the pertinence of implementing these markers in the clinical practice.

Keywords : Apolipoprotein A-I; Apolipoprotein B; Dyslipidemias; Adolescent.

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