SciELO - Scientific Electronic Library Online

 
vol.34 issue2Association of 4-hydroxynonenal with classical adipokines and insulin resistance in a Chinese non-diabetic obese populationEffects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Abstract

MARIN, Flávia-Andréia et al. Micronutrient supplementation in gastric bypass surgery: prospective study on inflammation and iron metabolism in premenopausal women. Nutr. Hosp. [online]. 2017, vol.34, n.2, pp.369-375. ISSN 1699-5198.  http://dx.doi.org/10.20960/nh.1162.

Background:

Low-grade chronic inflammation in morbid obesity is associated with impaired iron metabolism. Bariatric surgery is effective in weight loss; however, it can induce specific nutritional deficiencies, such as iron, especially in premenopausal women. Alternatively, after surgery, there is an improvement in systemic inflammation, raising questions concerning the dosages of micronutrient supplementation.

Objectives:

This study aimed to assess the effect of two micronutrient supplementation schemes before and 6 months after a Roux-en-Y gastric bypass (RYGB) surgery on inflammation and iron metabolism in premenopausal women.

Methods:

This prospective study included 45 premenopausal women (aged 20-45 years; body mass index [BMI] ≥ 35 kg/m2) divided into two supplementation schemes: group 1 (n = 34): daily supplemental dose of 1 RDA 30 days before surgery and 2 RDAs during the six months following surgery; and group 2 (n = 11): daily supplementation of 1 RDA during the 6 months postsurgery. Anthropometry, dietary intake, inflammation, and iron metabolism were monitored.

Results:

Evident reductions in BMI, high-sensitivity C-reactive protein, and ferritin levels for both groups occurred 6 months after surgery. Additionally, anemia was 9% in both groups after surgery. However, group 1 exhibited an increased transferrin saturation index and reduced transferrin levels. Multivariate regression analysis suggested serum iron, hepcidin, and iron intake determined ferritin values before and after RYGB surgery.

Conclusion:

Six months after RYGB, systemic inflammation was reduced in both supplementation schemes. However, supplementation of 1 RDA before and 2 RDAs after surgery resulted in better improvements on iron metabolism.

Keywords : Obesity; Inflammation; Iron; Bariatric surgery; Micronutrient supplementation.

        · abstract in Spanish     · text in English     · English ( pdf )