Abstract

CORELLA, Dolores  and  ORDOVAS, José Mª. The role of omics in precision nutrition: strengths and weaknesses. Nutr. Hosp. [online]. 2018, vol.35, n.spe4, pp.10-18.  Epub Sep 28, 2020. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.2119.

Precision medicine has taken huge strides forward in recent years. Although there is still no generally accepted single definition, it basically considers the particular characteristics of each person as relevant in order to better adapt therapeutic or preventive measures in a more personalized fashion.

Likewise, the concept of precision nutrition has gathered strength, in which the aim is to provide the best dietary recommendations to prevent or treat a disease in accordance with the characteristics of the individual in question. Of special importance among these characteristics are those based on omics. Initially genomics, and now epigenomics, metabolomics, proteomics and transcriptomics are providing us with new information on the different responses to the diet based on genotype, on new early biomarkers of disease, on dietary intake, or on the regulatory effects of diet. However, precision nutrition can go further still to include much more holistic aspects, not focusing on the disease, but on wellbeing and other indicators of positive health. Hence, other omics have been added to those mentioned above that provide us with a more multidimensional analysis.

Gastronomy also plays an important role in precision nutrition. Although we are still at the preliminary validation stage of precision nutrition, this field presents huge potential for development.

In this context, we shall review the role of omics in precision nutrition as well as their main strengths and weaknesses.

Keywords : Omics; Diet; Precision nutrition; Genomics; Epigenomic; Transcriptomics; Metabolomics; Proteomics; Computational Biology.

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