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Nutrición Hospitalaria
On-line version ISSN 1699-5198Print version ISSN 0212-1611
Abstract
PARADA, Alejandra; AGUIRRE, Carolina and PEREZ-BRAVO, Francisco. Overweight and obesity in celiac disease: expression of the interleukin profile Th17. Nutr. Hosp. [online]. 2018, vol.35, n.4, pp.957-961. Epub Nov 18, 2019. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.1554.
Introduction:
the histological alteration in the small intestine of the celiac patients produces a poor absorption that deteriorates or hinder an optimal weight gain. This can be the result of an increase expression of the Th17 gluten-specific interleukins.
Objective:
the aim of this study was to compare the expression of Th17 interleukins in celiac patients with normal and overweight/obese nutritional status.
Methods:
a total of 22 patients with newly diagnosed celiac disease were eligible: 15 patients with normal weight and seven overweight/obese. Small intestine biopsies were taken for the evaluation of the expression of interleukins through real-time PCR.
Results:
expression levels of Th17 interleukins showed a tendency to be higher in intestinal biopsies of overweight/obese patients compared to normal weight celiac subjects; however, this difference was not statistical significant.
Conclusion:
body weight excess in celiac patients is not influenced by the expression levels of Th17 interleukins.
Keywords : Celiac disease; Interleukins; Overweight.
