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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Abstract

BELTRAN-PINA, Blanca-G.; GONZALEZ-CASTRO, Martha-Irene  and  RIVAS-GARCIA, Francisco. Influence of amino acids that come from the diet in the expression of genes. Nutr. Hosp. [online]. 2019, vol.36, n.1, pp.173-182. ISSN 1699-5198.  http://dx.doi.org/10.20960/nh.1986.

Objective:

to make a descriptive review about the influence of the dietary amino acids in gene expression.

Materials and method:

the bibliographic research included the following written sources: Scielo, PubMed, Medline, NCBI, Springer, Scopus, Science Direct and Elsevier, retrieved until May 2018 from critical reviews of scientific articles. One hundred and five records were found after the combination of key words. Fundamental selection criteria were taken into account (title, authors, summary and results) using Maeda's reasoned reduction and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) as a systematic review methodology.

Conclusion:

there are genes that are regulated in various stages including transcription, post-transcriptional processing, nuclear export and translation of mature mRNA. Amino acids can influence these processes through the activation of transcription factors. In terms of translation, amino acids can regulate protein synthesis through changes in eIF2B, phosphorylation of 4E-BP1 and S6 proteins. In addition, amino acids affect the regulation of the growth factor expression (insulin like grow factor: IGF-I) in humans.

Keywords : Gene expression; Amino acids; Protein synthesis; Glutamine; Arginine; mTOR.

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