SciELO - Scientific Electronic Library Online

 
vol.36 número5Modificación de la actividad física durante los tres primeros años de universidadEvaluación del riesgo de trastornos de la conducta alimentaria en jugadores semiprofesionales de deportes de equipo índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Nutrición Hospitalaria

versión On-line ISSN 1699-5198versión impresa ISSN 0212-1611

Resumen

KURI-GARCIA, Aarón et al. Effect on nutritional markers of a model of aberrant crypt foci induced by azoxymethane and sodium dextran sulfate in Sprague Dawley rats. Nutr. Hosp. [online]. 2019, vol.36, n.5, pp.1163-1170.  Epub 24-Feb-2020. ISSN 1699-5198.  http://dx.doi.org/10.20960/nh.02600.

Introduction:

aberrant crypt foci (ACF) are colon preneoplastic lesions that can be used as a tool to study preventive processes for colorectal cancer (CRC). This model consists of initiation induced by azoxymethane (AOM) and promoted by sodium dextran sulfate (DSS), simulating human colonic carcinogenesis in a rat model. There is no direct information on the effects of this process on nutritional markers.

Objective:

to determine the effect on nutritional markers after the induction of ACF by AOM/DSS in a rat model.

Methods:

ACF were induced in 24 four-week-old Sprague Dawley male rats by administration of 2 AOM injections (10 mg/kg) and 7 days of 2% DSS in their drinking water. Body weight gain, food and fluid intake, weight of sacrificial organs, nutritional biochemical profiles, liver and kidney toxicity were evaluated. Cell counts in blood were also performed and histological sections evaluated in specific organs. The model was confirmed with identification and counts of ACF. Half of the rats were sacrificed at the sub-chronic stage and the rest at the chronic stage.

Results:

at the sub-chronic stage, changes in the liver and colon weight, and in the lymphocyte count were observed. For both stages, histopathological damage was observed in liver, kidney and colon, along with alterations in serum glucose levels.

Conclusions:

the model for proposed ACF can be used at the sub-chronic stage without the need for observation at the chronic stage. More research is needed to determine the mechanism of the observed effects.

Palabras clave : Azoxymethane; Dextran sulfate sodium; Nutritional effects.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )