Resumo

POVEDA GOMEZ, F. et al. Pattern of erythropoietin and proinflammatory cytokines in serum from patients with anemia of chronic disorders secondary to infection. An. Med. Interna (Madrid) [online]. 2001, vol.18, n.6, pp.14-22. ISSN 0212-7199.

Objective: To evaluate the pattern of erythropoietin (EPO) and some proinflammatory cytokines in the anemia of chronic disorders (ACD) secondary to infection Methods: Sequential determination in serum of interleukin-1 beta (IL-1β), necrosis tumoral factor alpha (TNF-α), gamma interferon (IFN-γ), interleukin-6 (IL-6), and erythropoietin (EPO) in 25 patients with chronic bacterial infectious diseases and ACD criteria. We evaluated the relationship of these mediators with the anemia and the iron metabolism.Results: Serum EPO levels significatively decreassed compared with initial values, and the last control was in normal rank (18.04 ± 19.10 vs. 8.56 ± 4.72 UI/mL; p < 0.001; normal rank: 4-15 mUI/mL). In the first control, there was a negative and non significative correlation between the EPO levels and the hemoglobin concentration (r = -0.115, NS), reaching significance in the last control (r = -0.446; p < 0.05). There was negative correlation between the hematocrit and TNF-α levels (r = 0.467; p <0.05) and between the haemoglobin values and the log of serum TNF-α (r = 0.424; p <0.001). An inverse correlation between the IL-6 levels and both, the hemoglobin concentration and the serum iron was found, and there was a direct correlation between this cytokine values and the EPO levels.Conclussions: Blunted response of erythopoietin and the action of TNF may contribute to the pathogenesis of ACD secondary to infection. Positive correlation between IL-6 and EPO suggest a proerythropoietic action of IL-6 in response to the anemia.

Palavras-chave : Anemia; Infection; Erythropoietin; Cytokines.

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