Resumo

PAZOSANON, R. et al. Antimicrobial susceptibility of the bloodstream infections: a study in a non teaching hospital. An. Med. Interna (Madrid) [online]. 2004, vol.21, n.10, pp.23-27. ISSN 0212-7199.

Background: To try established antimicrobial susceptibility patterns and frequency of both nosocomial and community-acquired bloodstream infections and to try identified the pronostic factors that can be modified. Material and methods: A prospective study of 310 bloodstream infections with clinical significance detected in a non teaching hospital over period from October 2000-2001. A blood culture were idenfied by Bact-Alert system and the confirmation was performed by MicroScan system; an antimicrobial susceptibility test was performed by reference microdilution methods as described by NCCLS. We studied sentinel antimicrobial /organism combinations with potencial clinical importance. Data were computerized using SPSS. Qualitative variables were compared using the X2 test or the Fisher exact test, and quantitative variables with t Student or ANOVA. Results: Gram positive and Candida were frequently recovered in nosocomial bloodstreams. The proportion of oxacillin-resistant S. aureus isolates was 24% and the penicillin resistant pneumococci was 14%.Vancomycin was universal active against gram positive. Gram negatives were often recovered in community bloodstream. The proportion of EBSL E. coli isolates was <2% and the proportion of multiresistance Pseudomonas aeruginosa was higher among UCI isolates. An independent risk factors for death identified after multivariate análisis was the inapropiate antimicrobian therapy OR 2.6. Conclusions: Ongoing surveillance of microbial pathogens and their resistance profiles is essential on local escale and permit the selection of appropiate antibiotic therapy which would be reduce the mortality.

Palavras-chave : Bloodstream; Antimicrobial susceptibility; Mortality.

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