Resumo

GALLEGOS-VILLANUEVA, MJ; CHIMENOS-KUSTNER, E; LOPEZ-LOPEZ, J  e  ROSELLO-LLABRES, X. Field cancerization: revision of the concept. Av Odontoestomatol [online]. 2007, vol.23, n.1, pp.35-44. ISSN 2340-3152.

The concept of field cancerization is related to a greater risk of develop one or more carcinomas, on those patients in usual contact with cancerous agents. This term designs several fields of precancerous disease, with more prevalence of multiple primary or secondary local tumours, and distant syncronical tumours as well. Some studies indicate frequent lateral clonal extension of the precancerous and cancerous lesions. The molecular technology has permitted to deep in the knowledge of the relationship between these lesions. In front of this pathology, there are investigated several preventive and therapeutical alternatives, like screening of the population, or administration of retinoids and genic therapy, that can be benefit for these patients.

Palavras-chave : Field cancerization; Oral precancer; Oncogenes; Squamous cell carcinoma.

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