SciELO - Scientific Electronic Library Online

vol.32 número1Impacto de lesiones orales sobre la calidad de vida en pacientes adultosMecanismo de acción de "plantas medicinales" aplicadas en lesiones estomatológicas: Revisión. Mecanismo de transferencia de energía mediante moléculas antiinflamatorias y antioxidantes absorbidas por los receptores de las membranas celulares de la mucosa oral. Hipótesis índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google


Avances en Odontoestomatología

versão On-line ISSN 2340-3152versão impressa ISSN 0213-1285


TIRADO AMADOR, L.R.; MADERA ANAYA, M.V.  e  GONZALEZ MARTINEZ, F.D.. Genetic and epigenetic interactions related to non-syndromic cleft lip and palate. Av Odontoestomatol [online]. 2016, vol.32, n.1, pp.21-34. ISSN 2340-3152.

At present the non-syndromic cleft lip and cleft palate is one of the impaired growth and development facial with high prevalence and causes worldwide preoccupation because generates effects at the physiological level because impact on swallowing, phonation, as well as the perception and acceptance of the individual on socialization. Resulting a treatment of this alteration with needs the use of an interdisciplinary team in order to achieve improvement to meet the needs of the individual concerned. About the etiology of this developmental defect, in the literature has been attributed to various genetic and environmental factors, converging towards the model multifactorial interaction in which genes emit response to stimuli from the environment, which affects the phenotypic expression level. Although there are reports of genetic changes that may be associated with alterations in development during palate closure, there is a great tendency to consider the presence of mutations; however occasionally it omitted or subtract some importance to the effects deriving from changes in the expression of genetic information as a result of exposure to certain environmental factors. Therefore in the present review, the authors attempt to describe some genetic and epigenetic factors involved in the emergence of non-syndromic cleft lip and cleft palate.

Palavras-chave : Epigenetic repression; cleft lip; cleft palate; environment; DNA methylation.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )