SciELO - Scientific Electronic Library Online

 
vol.78 número8Orbitopatía tiroidea (fisiopatología, diagnóstico y tratamiento)Optimización de una intervención de cirugía LASIK individualizada: Modelo óptico de trazado de rayos índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Archivos de la Sociedad Española de Oftalmología

versión impresa ISSN 0365-6691

Resumen

MERAYO, J et al. Effectiveness and impact in the quality of life of ketotifen ophthalmic solution: Results of ZETA study in patients with seasonal allergic conjunctivitis. Arch Soc Esp Oftalmol [online]. 2003, vol.78, n.8, pp.433-441. ISSN 0365-6691.

Purpose: To study the effectiveness of ketotifen ophthalmic solution (0.25 mg/ml) in seasonal allergic conjunctivitis (SAC) and the impact on the patient’s quality of life. Methods: A multicentric, longitudinal, prospective study was designed. 284 Spanish ophthalmologists participated recruiting 1145 patients with SAC. After obtaining the informed consent, a drop of ketotifen ophthalmic solution was instilled. At the visit, clinical symptoms pre and post-treatment were assessed. The patients answered a questionnaire of quality of life (QOL) pre-treatment and minimum one week after initiating the treatment. The qualitative variables were described by the percentage, and the quantitative were described by the average, median, standard deviation, and maximum and minimum values. The effectiveness (change of intensity of the symptoms) and the quality of life were studied by the Wilcoxon test with a significance level of 5% (α = 0.05). Results: Following the instillation of the ketotifen ophthalmic solution the intensity of the ocular symptoms (redness, edema, tearing, secretion, photophobia and visual acuity impairment) decreased significantly. Comparing both QOL, we observed a statistically significant reduction of the limitation perceived by the patients in their daily activities, animic state and ocular symptoms. In 0,7% some adverse event was referred, none was serious and only in one case the probable relationship with the drug was specified. Conclusion: The results of the ZETA study demonstrate the tolerability and effectiveness of the ketotifen ophthalmic solution for all the symptoms of SAC in clinical practice, observing improvement in the quality of life of the patient.

Palabras clave : Ketotifen ophthalmic solution; seasonal allergic conjunctivitis (SAC); effectiveness; tolerability; quality of life.

        · resumen en Español     · texto en Español

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons