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Archivos de la Sociedad Española de Oftalmología
versión impresa ISSN 0365-6691
Resumen
TORRES, RM et al. Ocular presentation in Wegener granulomatosis. Arch Soc Esp Oftalmol [online]. 2004, vol.79, n.3, pp.135-138. ISSN 0365-6691.
Case report: A 71 year-old female presented with bilateral conjunctivitis, scleritis and peripheral ulcerative keratitis. Ancillary tests showed presence of anti-neutrophil cytoplasmic antibodies, with diffuse granular cytoplasmic immunofluorescence staining (ANCAc). Conjunctival biopsy showed necrotizing vasculitis in small vessels. Diagnosis of Wegener Granulomatosis (WG) was established and upper respiratory affection detected. Treatment with megadoses of cyclophosphamide and corticoids was initiated and remission of the disease was obtained. Discussion: WG is a potentially lethal systemic vasculitis in which ocular involvement may be the first clinical presentation. Scleritis and peripheral ulcerative keratitis indicate systemic involvement, highlighting the importance of prompt diagnosis and treatment.
Palabras clave : Ulcerative keratitis; Wegener's Granulomatosis; Vasculitis; ANCA.