Archivos de la Sociedad Española de Oftalmología
versión impresa ISSN 0365-6691
GARCIA GARCIA, O; VIDALLER PALACIN, A; MUNOZ SANCHEZ, J y ROCA LINARES, G. Granulocyte-apheresis in ocular Behçets disease resistant to medical treatment. Arch Soc Esp Oftalmol [online]. 2004, vol.79, n.7, pp.335-340. ISSN 0365-6691.
Objective: To assess the feasibility of granulocyte apheresis (GCAP) in patients with Ocular Behçets Disease (BD) resistant to immunosuppressive therapy (prednisone, cyclosporin, azathyoprine or mycophenolate mofetil). Methods: Prospective observational study of five cases, carried out in a university centre. Four patients were resistant to medical treatment and one refused immunosuppressive drugs. The intervention procedure consisted of an extracorporeal GCAP using a column filled with cellulose acetate beads (Adacolumn, JIMRO, Takasaki, Japan). All patients received underwent a schedule of therapy of five sessions, once a week for five consecutive weeks. Visual acuity (Snellen lines), the degree of intraocular inflammation and doses of immunosuppressive therapy were measured and observed every week. Results: Visual acuity improved in the five cases. Intraocular inflammation was measured and observed in every case, relapses were avoided, and treatment with prednisone was reduced by more than half of the initial dose (average reduction 52.7%, SD 14). Conclusions: GCAP has been shown to be safe and effective as a new therapy in five cases of Ocular Behçets Disease refractory to medical treatment. Further research is needed in order to confirm the promising results of these initial investigations.
Palabras clave : Granulocyte-apheresis; Behçets disease; immunosuppressants.