Abstract

MARTINEZ, A.  and  SLOF, J.. Cost-efficacy analysis of fixed combinations of prostaglandin/prostamide for treating glaucoma. Arch Soc Esp Oftalmol [online]. 2008, vol.83, n.10, pp.595-600. ISSN 0365-6691.

Objective: To assess the cost-efficacy of three fixed-combination glaucoma treatments currently available in Spain [bimatoprost with timolol (BT)- Ganfort^®, latanoprost with timolol (LT)- Xalacom^®, and travoprost with timolol (TT)- DuoTrav^®]. Methods: Because no studies are available that give a direct comparison of these drugs, a systematic review was carried out to assess their efficacy. Resource consumption and costs were estimated using a model of usual local practice. For each of the three drugs, average and incremental cost-efficacy ratios were determined in terms of euros per percentage point of reduction of intraocular pressure (IOP) over a three-month period. Results: BT reduced IOP by 35.1%, LT by 35.0% and TT by 34.7%. Average cost-efficacy was estimated to be € 5.34 per percentage point of IOP reduction with BT, € 5.40 with LT, and € 5.45 with TT. Incremental cost-efficacy (incremental cost per incremental percentage point of IOP reduction) was estimated to be € 94.65 for LT vs. TT, and was negative for BT vs. TT and BT vs. LT, since in both cases BT was more efficacious and less expensive. Conclusions: Compared to travoprost/timolol and latanoprost/timolol, bimatoprost/timolol appears to be the most economic alternative, with equal or better efficacy and safety results.

Keywords : Glaucoma; cost analysis; beta-blocker; prostaglandin analogue; fixed combinations.

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