Abstract

MARIN-LAMBIES, C.; SALOM, D.; GARCIA-DELPECH, S.  and  DIAZ-LLOPIS, M.. Intraocular levels of pigment epithelium-derived factor in patients with active uveitis. Arch Soc Esp Oftalmol [online]. 2011, vol.86, n.3, pp.77-80. ISSN 0365-6691.

Objective: Pigment epithelium-derived factor (PEDF) is an antiangiogenic/neurotrophic dual functional factor, and recently it was also shown to mediate antioxidative and anti-inflammatory action. The purpose of this study was to evaluate the levels of PEDF in the aqueous humor in eyes with idiopathic acute anterior uveitis (IAAU). Methods: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with IAAU. The control group included 20 aqueous humor samples from 20 patients who underwent a cataract surgery and without any other ocular or systemic diseases. Levels of PEDF were determined with the ELISA test. Results: Concentration of PEDF in aqueous humor was remarkably higher in patients with IAAU than in control subjects (Mann-Whitney U test, P<.001). Levels of PEDF were 6,291,637.70±8,564,836.48 pg/ml (mean±SD) in eyes with IAAU and 449,178.10±158,670.19 pg/ml in the eyes of the control group. Conclusion: The aqueous humor PEDF levels are increased in eyes with IAAU and may be increased as self-protection against inflammation.

Keywords : Uveitis; Pigment epithelium-derived factor; Inflammation; Cytokines; Aqueous humor.

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