Abstract

D'OLIVEIRA-PAZOS, Lucía et al. Use of platelet rich plasma as prophylactic method for skin damageafter radiotherapy: experimental study. Cir. plást. iberolatinoam. [online]. 2016, vol.42, n.2, pp.109-114. ISSN 1989-2055.

Background and Objectives. Radiotherapy is usually associated with skin complications that affect the quality of life of patients and in some cases can also affect the timing of the reconstruction. The plateletrich plasma (PRP) is an emerging therapy; is autologous, safe and economic. Current use of PRP includes: efficacy in decreasing local inflammation, enhance wound healing, treatment of skin ulcers caused by radiotherapy and its use extends to the field of aesthetic plastic surgery improving the quality of the skin.The authors made an experimental trial to analyze the use of PRP as a prophylaxis method for skin damage after radiotherapy. We analyze the benefits of PRP as a prophylaxis method for skin damage after radiotherapy using an experimental model. Methods. We conduct a double blind trial with rats. Twelve Wistar rats were used, 2 for obtaining the PRP and 10 for clinical and histological analysis. Results. Data collected from the clinical analysis showed that those areas without PRP: 8 rats presented alopecia and 7 hypopigmentation. Total alopecia was present in 60%, partial alopecia in 20%, and 20% did not present alopecia. In those areas with PRP before radiotherapy: 4 presented alopecia and 3 hypopigmentation. There were no cases of total alopecia, 60% did not present alopecia and 40% presented partial alopecia. Data collected from the histological analysis showed 100% of mild-moderate atrophy in those areas with PRP. On the other hand, 80% of moderate-severe atrophy and 20% of mildmoderate atrophy was present on those areas without PRP. Conclusions. The authors showed the benefit of PRP as a prophylaxis method for alopecia (p < 0.05) and hypopigmentation (p < 0,1) produced after radiotherapy in this experimental model.

Keywords : Platelet-rich plasma; Radiotherapy; Radiodermithis.

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