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Cirugía Plástica Ibero-Latinoamericana

versión On-line ISSN 1989-2055versión impresa ISSN 0376-7892

Resumen

RUBIO-YANCHUCK, Mónica; TOLEDANO-REAL, Víctor  y  BONASTRE-JULIA, Jorge. Tolerance induction to endotoxin in a composite tissue transplant. Cir. plást. iberolatinoam. [online]. 2018, vol.44, n.3, pp.251-257. ISSN 1989-2055.  http://dx.doi.org/10.4321/s0376-78922018000300003.

Background and Objetive

Endotoxin tolerance is a biological phenomenon which consists in desensitization of immune system cells to low exposures to lipopolysaccharide (LPS). It leads to antigens anergy.

The aim of this study is to asses the development of tolerance after precondicioning with LPS in the context of a composite tissue transplant.

Methods

Transferences of hind legs were made between rats crossing the Main Histocompatibility Complex (MHC). The animals were divided into 2 groups according to the preconditioning they received, LPS and physiological saline.

Results

The control group presented a median survival of the allograft less tan 15 days after the cessation of inmunosupressive treat-ment. The group preconditioned with LPS presented median survival greater than 30 days (p=0.001).

Conclusions

The mechanism of tolerance to endotoxin increases the survival of composite tissue allotransplantation.

Palabras clave : Tissue transplantation; Composite tissue transplantation; Transplant survival; Endotoxin.

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