Abstract

PAREDES LARIO, A.; BLANCO GARCIA, C.  and  ECHENIQUE ELIZONDO, M.. Expression of proteins related to multiple drug resistance (MDR-proteins) in chemotherapy-resistant lung cancer. Oncología (Barc.) [online]. 2006, vol.29, n.6, pp.21-29. ISSN 0378-4835.

PURPOSE: To evaluate the expression of MDR-proteins in the response to lung cancer chemotherapy. METHODS: 147 tumor samples were collected from 143 patients, 35 of which were obtained by bronchoscopy and 112 from surgery; 101 samples belonging to 99 patients were considered valid for the study. The samples were cryopreserved and immunochemistry with monoclonal murine antibodies used to determine the MDR-proteins Pgp, Mrp1 and Lrp. RESULTS: No MDR-proteins were expressed in 16 cases. One MDR-protein was present in 32 cases: Pgp in 3, Mrp1 in 11 and Lrp in 18. Two MDR-proteins were expressed in 34 cases: Pgp and Lrp in 24, Mrp1 and Pgp in 5, and Mrp and Lrp in 5. All the three MDR-proteins were present in 17 cases. No differences were observed considering age (Pgp, p = 0.74; Mrp1, p = 0.95; Lrp, p = 0.26). Neither sex produced changes when considering either number of MDR-proteins (p = 0.55) or types of them (p = 0.21). Significant differences of MRD-proteins were also lacking for number (p = 0.59) and type (p = 0.51) in relation to the tumor histologic grade. The tendency to the simultaneous expression of Pgp and Lrp was very significant (p < 0.01), while the simultaneous expression of Mrp1 and Lrp showed to be no significant (p = 0.26). CONCLUSSIONS: Pgp and Lrp are frequently expressed simultaneously. Only the expression of Pgp and the number of MDR-proteins expressed simultaneously seem to be related to response to chemotherapy.

Keywords : MDR-proteins; Lung cancer.

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