Resumo

COBO DOLS, M. et al. Specific alterations in the serum amino acid profile of patients with lung cancer and head and neck cancer. Oncología (Barc.) [online]. 2006, vol.29, n.7, pp.17-24. ISSN 0378-4835.

PURPOSE: Metabolism of the immediate principles is altered in cancer patients, resulting in an altered serum concentration of amino acids. The aim of this study was to find specific serum amino acid profiles in patients with cancer of the lung or head and neck. MATERIAL AND METHODS: We analyzed the baseline serum levels of 27 amino acids in 51 patients with cancer of the lung or head and neck with no metabolic alterations or other concomitant disorders and compared the results with a control group. RESULTS: Compared with the control group, patients with head cancer had significant differences in cysteine, aspartic acid, 3-methyl histidine, alanine, glycine, lysine, methionine, proline, serine, taurine, tyrosine, and threonine; and patients with lung cancer in cysteine, aspartic acid, 3-methyl histidine, histidine, citrulline, ornithine, alanine, glycine, lysine, methionine, proline, serine, taurine, tyrosine, and threonine. CONCLUSIONS: Variation in serum levels of certain amino acids in head and neck cancer and lung cancer is probably caused by interaction of the neoplasm with the protein metabolism. Each type of tumor has a certain specificity in the serum amino acid profile that may be useful in the diagnosis of these tumors.

Palavras-chave : Amino acids; Lung cancer; Head and neck cancer.

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