Abstract

LUNA-SANCHEZ, Shirley  and  LOBETO MARTINEZ, María Ruth. Occupational exposure to chlorinated hydrocarbons and pancreatic cancer: review of recent literature. Med. segur. trab. [online]. 2014, vol.60, n.235, pp.406-419. ISSN 1989-7790.  https://dx.doi.org/10.4321/S0465-546X2014000200012.

The proportion of pancreatic cancer that can be attributed to occupational exposures is about 12 %, although that is a small percentage, these factors can be prevented and it is important to identify them. Some occupations have been associated with an increased risk of pancreatic cancer, and these apparently have a statistically significant association for exposure to organochlorine or chlorinated hydrocarbons. Objective: To review the recent scientific literature looking for evidence on the relationship between occupational exposure to organochlorines and pancreatic cancer. Methods: A search was conducted in major databases using related descriptors and applying relevance, inclusion and exclusion criteria; finally we selected 10 articles. Results: Three meta- analysis, three cohort studies and four case-control studies were analyzed, finding more bibliographic production between the 2000-2003 and 2007-2011 periods. Conclusions: Some exposures have been associated with increased risk for pancreatic cancer, but in most studies the effect is weak or moderate, often associated with the limited number of participants. Studies that investigate the association by type of occupation do not usually determine specific agents to which the worker is exposed, making it difficult to establish specific associations. It is important to continue studying gene-environment interactions related to the association with K-ras gene in search of more conclusive results that advance the field of prevention of occupational hazards..

Keywords : Occupational Exposure; Chlorinated Hydrocarbons; Pancreatic Neoplasms.

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