SciELO - Scientific Electronic Library Online

vol.96 issue4Tissue CA-19.9 content in colorectal adenomas and its value in the assesment of dysplasiaUsefulness of jejunal biopsy in the study of intestinal malabsorption in the elderly author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Española de Enfermedades Digestivas

Print version ISSN 1130-0108


NOVELL, F.; NOVELL-COSTA, F.  and  NOVELL, J.. Topical glyceryl trinitrate in the treatment of anal fissure. Rev. esp. enferm. dig. [online]. 2004, vol.96, n.4, pp.255-258. ISSN 1130-0108.

Aim: the aim of this study was to assess the effectiveness of topical glyceryl trinitrate (GTN) in the treatment of anal fissure. Patients: eighty consecutive patients were randomized to receive 0.2% GTN gel twice a day during a minimum of 6 weeks. Of these 80 patients 34 were males and 46 female, with ages be-tween 20 and 78 years. All patients underwent a work-up that included gender, age, symptom duration, site, previous treatment attempts, pain score, associated diseases, and maximum anal resting pressure. These patients were followed at regular intervals of 4, 8, and 12 weeks to assess symptom outcome, rate of healing, adverse effects, and recurrence rate. Results: pain scores were significantly reduced during the treatment period in 65% of cases. After 4 weeks, 55% of patients had healed, and 78% after 9 weeks. In 18 patients (22%), anal fissures did not heal even with 6 additional weeks of treatment, and 12 of them (15%) underwent lateral sphincterotomy. Sixty one percent of patients had flushing and 15% severe headaches. Conclusion: the results of this study have demonstrated the significant benefit of topical GTN when administered to patients suffering from anal fissures.

Keywords : Anal fissure; Gliceryl trinitrate; Surgical treatment.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License