SciELO - Scientific Electronic Library Online

 
vol.97 número2Prevalencia de la incontinencia anal y urinaria silentes en mujeres de la ciudad de TeruelLigadura de las arterias hemorroidales guiada por Doppler en el tratamiento de las hemorroides sintomáticas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista Española de Enfermedades Digestivas

versión impresa ISSN 1130-0108

Resumen

RODRIGO, L.; VINAS-SALAS, J.  y  PINOL-FELIS, C.. Effect of ethanol consumption on colon cancer in an experimental model. Rev. esp. enferm. dig. [online]. 2005, vol.97, n.2, pp.87-96. ISSN 1130-0108.

Aims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supplement of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) received ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental animals were sacrified after 25-27 weeks. Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E. Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dynamic model of tumor induction with DMH.

Palabras clave : Alcohol; Cancer; Carcinogenesis; Colon; Dimethylhydrazine; Ethanol; Tumors.

        · resumen en Español     · texto en Español | Inglés     · Español ( pdf ) | Inglés ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons