Revista Española de Enfermedades Digestivas
versión impresa ISSN 1130-0108
Introduction: a potential association between celic disease and inflammatory bowel disease hs been suggested, which may explain the fact that both disorders occasionally present in one patient or in his/her first-degree relatives more frequently than expected. Objective: to establish the prevalence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Method: a cross-sectional, prospective epidemiological study in a group of celiac patients, their first-degree relatives, and a control group with similar epidemiological characteristics including the relatives of patients presenting at the ER for acute conditions. A semistructured interview was used to identify the presence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Results: in all, 86 celiac patients and 432 relatives were included, who were compared to 809 control subjects (129 patients with acute conditions and 680 first-degree relatives). Three cases of Crohn's disease were identified among celiac patients, and 4 cases among their relatives. Only 1 case of Crohn's disease was detected in the control group (p < 0.01). No cases of ulcerative colitis were detected in any of the study groups. Conclusion: patients with celiac disease and their relatives have a greater predisposition to Crohn's disease versus the control population.
Palabras clave : Celiac disease; Crohn's disease; Ulcerative colitis; Epidemiology; Prevalence.