Revista Española de Enfermedades Digestivas
versión impresa ISSN 1130-0108
MARTIN, M. A. et al. Interleukin 18 (IL-18) and other immunological parameters as markers of severity in acute pancreatitis. Rev. esp. enferm. dig. [online]. 2008, vol.100, n.12, pp.768-773. ISSN 1130-0108.
Objective: our aim was to prospectively compare the behavior of interleukin 18 (IL-18) levels and other immunological parameters during the first week of hospitalization between acute pancreatitis patients with and without severity criteria, as well as between patients with and without late pseudocyst development. Patients and methods: in 36 patients with acute pancreatitis we compared sTNF-RI, IL-1Ra, IL-6, and IL-18 levels at days 1, 2, 3 and 7 after hospitalization between mild pancreatitis, severe pancreatitis, and a "control" group (13 patients) with uncomplicated biliary colic, as well as between patients with and without pseudocyst. Results: on comparing mild to severe pancreatitis, IL-18 was significantly higher only the first day in severe pancreatitis, while the other parameters were steadily higher after the second day. In patients developing pseudocyst, IL-18 was also noticeably higher the first day. Conclusions: IL-18 appears to be the earliest marker of complications and severity in acute pancreatitis at both the systemic and local level (pseudocyst).
Palabras clave : Interleukin 18; Acute pancreatitis; Severity; Pseudocyst.