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Revista Española de Enfermedades Digestivas

Print version ISSN 1130-0108


GONZALO, Sergio et al. Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances. Rev. esp. enferm. dig. [online]. 2012, vol.104, n.6, pp.305-309. ISSN 1130-0108.

Background: several diseases such as sepsis can affect the ileum. Lipopolysaccharide (LPS), an endotoxin present in the cell wall of gram negative bacteria, is a causative agent of sepsis. Objectives: the aims of this study were: a) to investigate the role of mitogen activated protein kinases (MAPKs) in the effect of LPS on the acetylcholine-induced contractions of rabbit ileum; and b) to study the localization of MAPKs in the ileum. Material and methods: ileal contractility was studied in an organ bath and MAPKs were localized by immunohistochemistry. Results: acetylcholine-induced contractions decreased with LPS. SB203580, SP600125 and U0126 blocked the effect of LPS on the acetylcholine-induced contractions. Phosphorylated p38 and ERK were detected in neurons of myenteric plexus and phosphorylated p38 and JNK in smooth muscle cells of ileum. Conclusion: we can suggest that p38, JNK, and ERK MAPKs are involved in the mechanism of action of LPS in the ileum.

Keywords : Intestinal contractility; LPS; p38; ERK; JNK; Myenteric plexus; Smooth muscle.

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