SciELO - Scientific Electronic Library Online

vol.106 issue4Hepatotoxicity associated with statin use: analysis of the cases included in the Spanish Hepatotoxicity RegistryPolycystic liver in the adult (PLA) in Spain: analysis of a structured survey analysing the experience and attitude of gastroenterologists in Spain author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista Española de Enfermedades Digestivas

Print version ISSN 1130-0108


SAPIDIS, Nikolaos et al. The effect of glutamine and synbiotics on the healing of colonic anastomosis. Rev. esp. enferm. dig. [online]. 2014, vol.106, n.4, pp.255-262. ISSN 1130-0108.

Introduction: Intestinal wound healing is an essential process for surgical reconstruction of the digestive tract. The purpose of this study is to evaluate the effect of perioperative administration of glutamine and synbiotics on the biological behavior of intestinal mucosal barrier and the healing of colonic anastomosis in rats. Material and methods: 80 Wistar rats were divided in five groups. A: Control. B: Mechanical bowel preparation and antibiotics. C: Glutamine. D: Synbiotics. E: Glutamine and synbiotics. The animals were sacrificed on 3rd and 7th postoperative day. Results: Zero mortality and no septic complications were noted. On 3rd postoperative days, a significant weight loss was observed in all groups in comparison with the preoperative weights, but on the 7th day in groups C and E, in contrast with the other groups, weight loss was not significant. On the 3rd postoperative day, neoangiogenesis, inflammatory infiltration and fibroblast activity were significantly enhanced in group E compared to control. On the 7th postoperative day in group E fibroblast activity was significantly enhanced and inflammatory infiltration was significantly limited compared to control. The bursting pressures as well as the hydroxyproline tissue content were significantly higher in the group E on 3rd and 7th postoperative days. The percentage of positive mesenteric lymph node cultures were significantly limited in group E compared to control. Conclusions: The administration of synbiotics in conjunction with glutamine resulted in increasing the mechanical strength of the anastomosis, thus increasing the bursting pressure and decreasing or effacing of anastomotic dehiscence and limiting bacterial translocation.

Keywords : Adhesion; Bursting pressure; Colon; Hydroxyproline.

        · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License