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Revista Española de Enfermedades Digestivas

Print version ISSN 1130-0108


CABEZAS, Joaquín et al. Causes of treatment failure for hepatitis C in the era of direct-acting antiviral therapy. Rev. esp. enferm. dig. [online]. 2016, vol.108, n.7, pp.421-430. ISSN 1130-0108.

Hepatitis C therapy in the era of the newer direct-acting antiviral agents has radically changed our treatment schemes by achieving very high rates of sustained virological response. However, treatment with direct antiviral agents fails in a subgroup of patients. This group of so-called difficult-to-treat individuals is the subject of this paper, which reviews the causes of virological failure, their clinical implications, and some final recommendations.

Keywords : Hepatitis C; Direct-acting antiviral therapy; Resistance-associated variants; Treatment failure.

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