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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


ARDILA MEDINA, C.M.. Base theories and the clinical application of bone morphogenetic proteins in maxillofacial surgery. Rev Esp Cirug Oral y Maxilofac [online]. 2009, vol.31, n.3, pp.151-156. ISSN 2173-9161.

One of the fundamental advances in bone neoformation has been the identification of important growth factors like the bone morphogenetic proteins that regulate live cartilage and bone differentiation. The cleansing, genetic cloning and expression of recombinant human bone morphogenetic proteins (BMP) have laid the basis for cellular and molecular analysis of bone development and regeneration. The genetic study of the BMPs indicates that they are essential to the normal development and function of animals. BMP post-natal bone development is also very important in embryonic organic, skeletal, craniofacial and dental tissue development. The availability of BMPs provides several challenges and opportunities to improve insights into the mechanisms that regulate the regeneration of bone for optimal outcome in the patient.

Keywords : Bone morphogenetic proteins; Bone regeneration.

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