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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


SANCHEZ-GUTIERREZ, Carlos et al. Efficacy of using plasma rich in growth factors in periodontal defects in lower distal second molar after extracting a mandibular third molar. Rev Esp Cirug Oral y Maxilofac [online]. 2017, vol.39, n.3, pp.164-170. ISSN 2173-9161.


The aim of this study was to evaluate the effectiveness of the application of plasma rich in growth factors (CFRP) in a distal periodontal defect of the lower second molars after extraction of a third molar.

Material and methods:

A randomised, controlled, and double-blind clinical trial, was conducted on 20 healthy patients with bilateral defects after the extraction of an impacted third molar. The patients were divided into experimental and control groups. Measurements of clinical attachment level were performed in the distal area of the second molar prior to surgery using an acetate splint in order to have the same reference measurement after the procedure. Post-surgical measurements were performed at 1, 4, and 12 weeks. These measurements, as well as evaluation times, were analysed using the Student t-Test, χ2 and Kruskal-Wallis Test.


The variables showed similarity in age, gender, difficulty, and length of the surgical times. The measurements prior to clinical insertion were 2.68 ± 0.56 vs. 2.63 ± 0.50 (experimental vs. control). During the first week after the procedure, the results were: 5.37 ± 1.81 vs. 5.35 ± 1.72; and at 3 months the recovery almost to baseline was similar in both groups (2.43 ± 0.89 vs. 2.55 ± 0.92).


No significant difference was found with the use of CFRP as regards achieving attachment at clinical level in the distal area of second molars after extraction of third molars.

Keywords : Impacted molar; Plasma rich in growth factors; Second molar; Periodontal defect.

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