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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


CASTANO-JOAQUI, Oscar Gabriel et al. Current status of viscosupplementation with hyaluronic acid in the treatment of temporomandibular disorders: A systematic review. Rev Esp Cirug Oral y Maxilofac [online]. 2017, vol.39, n.4, pp.213-220. ISSN 2173-9161.

Temporomandibular disorders are a set of related biological, psychological and social factors. Minimally invasive surgery of the temporomandibular joint is an effective treatment, and together with the use of hyaluronic acid this may reduce the signs and symptoms of patients with temporomandibular disorders.


To evaluate the additional clinical benefit of an injection of hyaluronic acid as single treatment or as an adjunct to minimally invasive surgery of the temporomandibular joint.

Material and methods:

An electronic search of databases Medline (PubMed) and the Cochrane Central Register of Controlled Trials (CENTRAL) was made using the terms ‘temporomandibular joint’, ‘temporomandibular disorders’, ‘hyaluronic acid’ and ‘sodium hyaluronate’. The selection criteria were: randomised controlled or quasi-randomised clinical trials evaluating the injecting of hyaluronic acid as a single procedure or with minimally invasive surgery of the temporomandibular joint.


A total of 8 studies were included in this review. Four of them compared the injection of hyaluronic acid with placebo. Two studies compared arthroscopy with hyaluronic acid versus arthroscopy without hyaluronic acid. Two studies compared arthrocentesis versus arthrocentesis with hyaluronic acid. The results using the clinical variables showed hyaluronic acid to be superior to placebo in the short term.


Due to the high risk of bias, more studies with better methodological design are needed in order to provide more reliable data for minimally invasive surgery of the temporomandibular joint with hyaluronic acid.

Keywords : Temporomandibular joint; Temporomandibular disorders; Hyaluronic acid; Sodium hyaluronate.

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