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Revista Española de Cirugía Oral y Maxilofacial

On-line version ISSN 2173-9161Print version ISSN 1130-0558


GAVIN-CLAVERO, Marina Alexandra et al. Diagnosis, treatment and follow-up of a recently described tumour: Mammary analogue secretory carcinoma (MASC) of the salivary gland. A report of 2 new cases. Rev Esp Cirug Oral y Maxilofac [online]. 2017, vol.39, n.4, pp.221-228. ISSN 2173-9161.


Mammary analogue secretory carcinoma (MASC) is a new salivary gland tumour with few cases reported. Pre-operative diagnosis is difficult, and treatment and follow-up are still under study.

Material and method:

A systematic review was conducted on 367 parotid tumours treated between January 2011 and December 2015 at the University Hospital Miguel Servet, Spain. Of the 367 cases operated on, 45 were malignant, and of these, only two cases were MASC.


Of the 367 parotid tumours reviewed, 45 were malignant, and two of them MASC. Sub-total and superficial parotidectomy combined with radiation therapy has been the treatment of choice. They showed no recurrence after 12 and 18 months.


A review is presented on the studies published in the literature on the differential diagnosis with other salivary gland tumours, taking into account their cytological and immunohistochemical results, focussing on the most specific markers for the diagnosis of MASC.


Pre-operative diagnosis of MASC is rarely successful. Its treatment and long-term survival is largely unknown, thus there is a need for more prospective studies, as well as new cases that should be documented and followed-up.

Keywords : Parotid gland; Mammary analogue secretory carcinoma; Treatment; Follow-up.

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