SciELO - Scientific Electronic Library Online

 
vol.22 issue6Prospective assessment of complications associated with ultrasound activated resorbable pin osteosynthesis in pediatric craniofacial surgery: preliminary results author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Neurocirugía

Print version ISSN 1130-1473

Abstract

RODRIGUEZ-MENA, R.; BARBELLA-APONTE, R.A.; GALLEGO-SANCHEZ, J.M.  and  BARCIA-MARINO, C.. Adult medulloblastomas: our experience. Neurocirugía [online]. 2011, vol.22, n.6, pp.488-497. ISSN 1130-1473.

Introduction: Medulloblastomas are malignant, invasive and highly cellular tumours from the cerebellum, rarely seen in adults. We describe the experience in the treatment of this entity in our institution. Materials and methods: A retrospective study was made including 11 adult patients with medulloblastomas confined to the craniospinal axis treated between 1984-2010. Clinical, radiological and therapeutic data were assessed during the evolution of this entity. Results: Mean age of patients was 30,2 years (9 women/2 men). Over 80% of the patients presented intracranial hypertension, while 54,5% presented cerebellum syndrome. Gross total surgical resection was achieved in 8 patients (72,7%) and subtotal resection in the other 3 (27,3%). All patients received craniospinal radiotherapy. After primary surgical resection, 6 patients received chemotherapy with cisplatin (CDDP) and etoposide (VP-16). During the follow up period and after a median time of 35,2 months, 4 patients (36,4%) presented with relapse, mainly in the posterior cranial fossa, managed in the majority of cases with surgical resection plus additional chemotherapy. Mean survival time was 100,3 months with a 5-and 8-year overall survival rate of 84 and 56% respectively. Conclusions: In the treatment of this malignancy, gross surgical resection has a crucial role, followed as soon as possible by oncological therapy, specially radiotherapy and chemotherapy if needed.

Keywords : Adult; Chemotherapy; Craniospinal radiotherapy; Medulloblastoma; Surgery.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License