Revista de la Sociedad Española del Dolor
versión impresa ISSN 1134-8046
GARCIA-GARCIA, J. A.. What need to know the Proton Pump Inhibitors to use in the chronic pain clinic?. Rev. Soc. Esp. Dolor [online]. 2007, vol.14, n.7, pp.501-510. ISSN 1134-8046.
Protón Pump Inhibitors (PPIs) have shown their usefulness in the treatment of acid-related disorders, highly prevalent in normal population. Pain units are used to treating patients with a wide range of diseases, including acid related-disorders, who are also being prescribed many different drugs, like NSAIDs, corticosteroids or biphosponates, which may reactívate or even worsen acid-related disorders. Knowledge of the pharmacological aspects of PPIs, both their pharmacokinetics and pharmacodynamics, is needed to properly choose the one which fits most to our multi-pathologic, multi-treated patients, in order to avoid possible pharmacological interactions than could endanger their health condition.
Palabras clave : Proton Pump Inhibitors; omeprazole; pantoprazole; lansoprazole; rabeprazole; esomeprazole; hepatic metabolism; pharmacological interactions.