Introduction:

Epigenetics refers to changes in DNA and histones that do not involve alterations in the nucleotide sequence and modify the structure and condensation of the chromatin, thus affecting gene expression and phenotype. Epigenetic modifications are DNA methylation and histone modifications.

Objective:

To carry out a review of the literature on the importance of Epigenetics in the pathophysiology and treatment of pain.

Materials and methods:

A review of the literature on the concept of epigenetics, its biological bases, the impact on pain and its relation to possible treatments.

Results:

Epigenetic mechanisms have become increasingly important due to the growing association with complex and common diseases, as well as their influence on pain and its possible treatments.

Conclusions:

Epigenetics has a clear relationship in pain, its pathophysiological bases and possible treatments.

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