SciELO - Scientific Electronic Library Online

vol.85 issue1Use of Services and Costs in Patients with Influenza (H1N1) 2009 in Spain: Background and Research ProtocolSurveillance the Pandemic Influenza (H1N1) 2009 in Catalonia: Results and implications author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista Española de Salud Pública

On-line version ISSN 2173-9110Print version ISSN 1135-5727


CALAFELL I MAJO, Francesc  and  GONZALEZ CANDELAS, Fernando. Genetic Factors in Severe Cases of (H1N1) 2009 Influenza. Rev. Esp. Salud Publica [online]. 2011, vol.85, n.1, pp.33-36. ISSN 2173-9110.

The pandemic influenza (H1N1) 2009 raised a number of issues, of which we address the following: Why did between 25 and 30% of severe influenza cases show no obvious risk factor? We hypothesize that an element that can contribute to the answer are host genetic risk factors involved in poor disease progression. Several indications led us to this hypothesis: i) studies of familial aggregation in Iceland and Utah Mormons show some heritability of influenza mortality; ii) nearly 300 known human genes are necessary for the replication of the influenza virus, and iii) the most severe cases of influenza A (H1N1) 2009 showed a deregulation of the adaptive immune system. We are addressing this problem through a case-control design (hospitalized cases of influenza (H1N1) 2009 confirmed against outpatient cases, also confirmed for (H1N1) 2009), which will be genotyped for more than a million single nucleotide polymorphisms (SNPs) and copy number variations (CNVs).

Keywords : Influenza; human; Outbreak; Pandemic; Genomewide association studies.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License