SciELO - Scientific Electronic Library Online

 
vol.33 número1Calidad de los hábitos alimentarios (adherencia a la dieta mediterránea) en los alumnos de educación secundaria obligatoriaPercepción y hábitos de salud bucodental en niños y adolescentes de Navarra, 2007 índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Anales del Sistema Sanitario de Navarra

versión impresa ISSN 1137-6627

Resumen

AIBAR, M. A.; LABORDA, K.; CONGET, F.  y  CORNUDELLA, R.. Hypercoagulability state and endotelial injury in stable chronic obstructive pulmonary disease patients. Anales Sis San Navarra [online]. 2010, vol.33, n.1, pp.43-50. ISSN 1137-6627.

COPD is currently the fourth cause of death in our country; the main causal agent of the disease is tobacco whose effects on the bronchial tree are not limited to the lung parenchyma. The action of tobacco injures the endothelial wall, which could contribute to lung thrombosis, ischemic events or secondary pulmonary hypertension. Our work investigates the existence of a prothombotic state in these patients, characterized by the activation of clotting and endothelial injury, comparing the values of biochemical markers between COPD patients and healthy volunteers. Fifty-one patients with COPD and a group of 30 healthy volunteers of similar ages were selected and fibrinogen, D-dimer, factor VIII and von Willebrand factor (FvW:Ag and FvW:Rico) levels were compared. We found an increase of all markers in the patient group compared to the healthy control group. The differences found were statistically significant in all cases (p<0.05). COPD is characterized by a state of hypercoagulability and endothelial injury that they could contribute to the development of vascular complications such as lung thrombosis, ischemic events or secondary pulmonary hypertension.

Palabras clave : Hypercoagulability state; Endothelial injury; COPD.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons