Abstract

DIAZ COBOS, D.; LAPARTE, C.; RUIZ-ZAMBRANA, A.  and  ALCAZAR, J.L.. First trimester screening of late-onset preeclampsia in a low risk and low volume obstetrical setting: external validation of a predictive model. Anales Sis San Navarra [online]. 2015, vol.38, n.3, pp.387-396. ISSN 1137-6627.  https://dx.doi.org/10.4321/S1137-66272015000300003.

Background: The external validation of predictive model of late preeclampsia in a low volume and low risk obstetrical setting. Methods: A cohort was created of 174 singleton pregnancies of 11⁺⁰-13⁺⁶ gestational weeks at Clinica Universidad Navarra from September 2011 to March 2013, which was considered as a validation cohort of a previously described model for late PE (Hospital Clinic, Barcelona). Results: A total of 7 (4%) women developed late PE. In the validation cohort the area under the curve of the model was 0.69 (95% CI 0.45-0.93). Detection rates for a 5, 10 and 15% of false positive rates were 21.9, 31.4% and 38.6% respectively. When comparing the areas under the curve of the validation cohort with the construction cohort, no statistical differences were found (p=0.68). Conclusion: The combination of maternal history, pregnancy associated plasma protein-A and mean arterial pressure is moderately useful to predict preeclampsia in a low risk and low volume obstetrical setting. The predictive model of the Clinic Hospital of Barcelona is a valid tool in predicting late preeclampsia in this setting.

Keywords : Preeclampsia; External validation; Predictive model; Low risk patients; Low obstetric setting.

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