SciELO - Scientific Electronic Library Online

vol.13 issue4Clinical skills at the pediatric patient with severe asthma of Pediatrics and Emergency residents author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Educación Médica

Print version ISSN 1575-1813


BOSCH, F.  and  BANOS, J.E.. Filling the gap: the usefulness of history of science to understand the process of drug research and development. Educ. méd. [online]. 2010, vol.13, n.4, pp.255-262. ISSN 1575-1813.

Introduction. Traditionally, social and experimental sciences have followed different paths, which have led to the creation of an artificial separation between them. One of the clearest examples that has tried to avoid this situation is the creation of disciplines such as the history of science, which helps to bring both closer together. However, the perception among scientists regarding the interest of history is not optimal, despite the undoubted virtues that the latter contains. Materials and methods. In this article the experience of using historical events to contribute to learning of complex processes, such as research and development of new drugs, is described. The use of two cases is outlined that were successfully completed and awarded the Nobel Prize: the modification of neurotransmitters´ structure to obtain new drugs (emasculated hormones) by James Black, and the application of the antimetabolite concept to design drugs for infectious, cancer and endocrine diseases. Conclusion. A teaching approach is remarkably successful in helping students understand the complexities of research and drug development.

Keywords : Antimetabolite; Cimetidine; Drugs; History of science; Pharmacology; Problem based learning; Propranolol; Research and development.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License