Avances en Periodoncia e Implantología Oral
versión impresa ISSN 1699-6585
MESA, FL et al. El Metronidazol en los agrandamientos gingivales secundarios a Ciclosporina A. Avances en Periodoncia [online]. 2002, vol.14, n.2, pp.69-74. ISSN 1699-6585.
Background: Drug-induced gingival overgrowth (GO) remains a significant problem for the periodontologist. Partial and total regressions of this GO have been reported after a short course of antibiotics. Methods: We conducted a double-blind controlled randomized study in order to determine the effect of 7 days of metronidazole treatment (250 mg /3 times day) on the regression of incipient cyclosporin Ainduced GO in adult renal transplanted patients. The quantitation of the GO was performed with lmage Digital Analysis. Results: At the end of the study, none of the 26 patients in the trial showed complete remission of the GO. Before treatment, the GO index was 0.90 ± 0.16 in the patients treated with metronidazole (MNZ group =13) and 1.11± 0.33 in the controls (placebo group =13). At the end of the study (30 days) the GO index score was lower in 54.4% of the MNZand the difference between groups was statistically significant (MNZ 0.92 ± 0.28vs. placebo 1.18± 0.3,p <0.05 Student's t test. Conclusions: The results of our present study indicate that a 7-day course of metronidazole does not induce the complete remission of CsA-induced gingival overgrowth but can partially abate the progression of the GO,probably through a decrease in the bacterial overinfection and gingival inflammation.
Palabras clave : Metronidazole; cyclosporin A; gingival overgrowth.