Abstract

LINARES, J.  and  MARTIN-HERRERO, J.E.. Farmacobiological concepts in the antibiotic treatment of the periodontal diseases. Avances en Periodoncia [online]. 2003, vol.15, n.3, pp.139-147. ISSN 2340-3209.

Periodontal disease must be considered a chronic bacterial infection. It does not appear to one single bacterial species that is uniquely involved. Rather, periodontal disease seems to be a polymicrobial infection involving several organisms. The bacteria most often associated with periodontal disease are Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus y Treponema denticola. Pharmacodynamics parameters are very useful to select dosing regimens. The increase in prevalence of resistance occurred in some periodontopathogens in the last years has pushed some antibiotics into the background. Positive responses have been reported with amoxicillin/clavulanate, metronidazole, clindamycin, doxycycline and the combination therapy metronidazole plus amoxicillin and metronidazole plus amoxicillin/clavulanate.

Keywords : Periodontal disease; antibiotics; resistance; pharmacodynamic.

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