Abstract

GONZALEZ QUESADA, J.; JORQUERA CORTES, R.; JORQUERA CORTES, O.  and  RIVERA ALVAREZ, S.. Levels of interleukin-17 in gingival crevicular fluid (CGF) of progressive chronic periodontitis patients. Avances en Periodoncia [online]. 2009, vol.21, n.3, pp.157-162. ISSN 2340-3209.

Biomarkers harvested from gingival crevicular fluid (GCF) may be useful to identify and predict periodontal disease progression and to monitor the response to treatment. Interleukin-17 (IL-17) is a T-cell-derived cytokine that play a important role in the initiation or maintenance of the pro-inflamatory response and has recently been found to stimulate osteoclastic resorption. These biological functions are relevant to the aetiopathogenesis of periodontitis. Aim: The purpose of the present study was to determine the presence of IL-17 in gingival crevicular fluid (GCF) of progressive chronic periodontitis patients. Method: GCF samples were collected with Periopaper from 14 active sites and 14 inactive sites determine by the tolerance method (Haffajee, 1983). The amount of IL-17 was determined by Human IL-17 Inmunoassay, Quantikine, R&D, Inc, Minneapolis, USA. The statistical data was analysed by Stata 7.0 using an unpaired Student t-test. Results: The levels of IL-17 were significantly higher in active sites than inactive sites (p=0,0005). Conclusions: These findings suggest that IL-17 could be a good marker for future attachment and alveolar bone loss.

Keywords : Gingival crevicular; biomarkers; progressive chronic periodontitis; osteocalcine.

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