Avances en Periodoncia e Implantología Oral
versión impresa ISSN 1699-6585
ARDILA MEDINA, C.M.. Non-steroidal anti-inflammatory as an adjunct to scaling and root planning in periodontitis. Avances en Periodoncia [online]. 2012, vol.24, n.1, pp.39-46. ISSN 1699-6585.
Periodontal tissue destruction occurs as a result of the interaction between dental plaque bacteria and the immunoinflamatory response induced by mediators like host enzymes, cytokines, and arachidonic acid metabolites such as prostaglandins (PGs). PGs play a role in the regulation of diverse cellular functions under physiological and pathological conditions. The ciclooxigenase (COX) enzyme providing the conversion of AA to PGs exists in two functionally distinct COX isoforms: COX-1 and COX-2. COX-2. The COX-2, is induced after stimulation by a variety of inflammatory cytokines, growth factors, and lipopolysaccarides. Higher expressions of COX-2 in periodontitis results in increases of the levels of prostaglandin E2 which are major mediators of periodontal tissue destruction. Non-steroidal anti-inflammatory drugs inhibit the production of COX products and can attenuate the progression of periodontal bone loss, become a therapeutic alternative for the management of periodontitis.
Palabras clave : Anti-inflammatory agents; non-steroidal; ciclooxigenase; periodontitis.