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Revista Clínica de Medicina de Familia

On-line version ISSN 2386-8201Print version ISSN 1699-695X


AZPIAZU GARRIDO, Mercedes  and  MUNOZ HERNANDEZ, Isabel S.. Adequacy and safety in Proton Pump Inhibitors (PPIs) chronic use. Rev Clin Med Fam [online]. 2017, vol.10, n.2, pp.70-77. ISSN 2386-8201.


To evaluate the adequacy of PPI chronic use, the factors associated to it and the presence of possible adverse effects.


Retrospective observational study.


Urban health centre.


109 of the 242 patients aged 40 to 85 who consumed PPIs over 12 months in 2013 and 2014.

Main measures:

Sex, age, active ingredient, consumption time (months), indication, current adequacy, comorbidity, chronic treatments and presence of adverse effects. Random sampling from two doctor quotas. Review of medical records.


Average age: 70.9 (SD: 10.1) years old. Women: 58.7 %. 83.5 % consumed omeprazole. Median consumption time: 96 months (interquartile range: 60-132). PPIs were indicated for gastroprotection (55 % ), GERD (9.2 %) and nothing (35.8 %). Current consumption was appropriate in 64.2 % (37 % in aged <65 vs 73.2 % in aged >65, p=0.001). Average number of comorbidities was 2.3 (SD: 1.1) diseases. Osteoarthritis and depression were more common in women while vascular disease, lung disease and liver disease were more common in men. The average number of chronic medications was 5.7 (SD: 2). Pneumonia (24.8 %), vitamin B12 deficiency (6.4 %) and osteoporosis (31.2 %) were concomitant diseases during PPI consumption. Patients with appropriate PPI chronic consumption were older, had more comorbidities (mainly vascular disease and anxiety-depression), and used more medications (among them, antiplatelet drugs, SSRIs, gastroerosive NSAIDs.


75 % of the sample showed a PPI chronic use of over 5 years. 35.8 % used PPIs without justified indication. Corrective measures are therefore required to improve patient safety.

Keywords : Proton Pump Inhibitors; Inappropriate Prescribing; Patient Safety.

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