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Revista Clínica de Medicina de Familia

On-line version ISSN 2386-8201Print version ISSN 1699-695X


LOPEZ GALLARDO, Yolanda; MARANES ANTONANZAS, Ignacio; FERNANDEZ SAEZ, Ana Belén  and  CORDERO BERNABE, Rubén. Primary amyloidosis and multiple myeloma, a frequent association. Rev Clin Med Fam [online]. 2020, vol.13, n.2, pp.157-161.  Epub Sep 21, 2020. ISSN 2386-8201.

Primary amyloidosis (PA) is the most common form of amyloidosis and is characterised by a clonal population of plasma cells which produce a lambda or kappa monoclonal light chain. In some subjects, this chain is deposited in the form of amyloid on organs and tissues, causing clinical expressions such as proteinuria or nephrotic syndrome, restrictive cardiomyopathy, and hepatomegaly.

Multiple myeloma (MM) is a neoplastic disease with plasma cell proliferation in the bone marrow and overproduction of complete monoclonal immunoglobulins. It represents 13 % of hematologic cancers and the average age at diagnosis is 65 years. Bone pain, pathological fractures, and hypercalcemia are the main clinical expressions. The prevalence of PA associated with MM ranges from 13 to 26 %. We present the case of a woman with PA associated with MM, with unique features during its course.

Keywords : Amyloidosis; Multiple Myeloma; Macroglossia.

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