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Revista de Osteoporosis y Metabolismo Mineral

versão On-line ISSN 2173-2345versão impressa ISSN 1889-836X

Resumo

RUBERT, M.; MARTINEZ-CALATRAVA, M.J.  e  DE LA PIEDRA, C.. Normal values of the aminoterminal propeptide of type I collagen (PINP) and the isomer beta I collagen carboxyterminal telopeptide (β-CTX) in serum of healthy premenopausal women of the Community of Madrid. Rev Osteoporos Metab Miner [online]. 2014, vol.6, n.1, pp.20-22. ISSN 2173-2345.  http://dx.doi.org/10.4321/S1889-836X2014000100005.

Introduction: In the laboratory it is sometimes difficult to find the normality intervals of the population itself, there being a tendency to give the normality value specified by the manufacturer of the reagent. The aim of this work was to calculate the normality values for aminoterminal propeptide of type I collagen (PINP) and for the beta isomer of carboxy-terminal telopeptide of type I collagen (β-CTX) in the blood of a group of premenopausal women from the autonomous Community of Madrid. Materials and methods: The study was carried out in 50 healthy premenopausal women between 27 and 40 years of age (mean ± standard deviation of 34±3 years, working in a hospital and a pharmaceutical laboratory in Madrid. Blood levels of PINP and β-CTX were determined using the technique of electrochemiluminescence (Elecsys, Roche). Results: Normal values of 36.2±12.9 ng/ml (range 10.4 to 62) for PINP and 0.306±0.121 ng/ml (range of 0.064 to 0.548) for β-CTX were obtained. Conclusions: Although the population sample used was small and localised, we consider that these values may be used as the normality interval for Spanish women.

Palavras-chave : normality interval; PINP; β-CTX.

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