Abstract

ARNAIZ DE LAS REVILLAS, F. et al. General and bone pain syndrome in a patient treated with tenofovir. Rev Osteoporos Metab Miner [online]. 2015, vol.7, n.4, pp.112-114. ISSN 2173-2345.  https://dx.doi.org/10.4321/S1889-836X2015000400006.

Tenofovir (TDF), is the only nucleotide analogue reverse transcriptase inhibitor for treating human immunodeficiency virus (HIV). Occasionally, it may cause acute renal failure and Fanconi syndrome. We report the case of a 64-year-old male diagnosed with HIV infection 22 years previous and treated with tenofovir. In outpatient follow-up, the patient complained of progressive fatigue and diffuse aching bones. In several check-ups, increased alkaline phosphatase and parathyroid hormone (PTH) were observed. Over the past month, his condition worsened and he was admitted to hospital. Analytical data included marked glycosuria, hypophosphatemia, hyperphosphaturia and hypouricemia. All changes were resolved when TDF was discontinued.This illustrates the importance of clinical evaluations that include possible TDF-induced proximal tubulopathy in patients with general bone pain syndrome or mineral metabolism disturbances.

Keywords : general syndrome; tenofovir; osteomalacia; Fanconi syndrome.

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