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Revista de Osteoporosis y Metabolismo Mineral
On-line version ISSN 2173-2345Print version ISSN 1889-836X
Abstract
SALMON-GONZALEZ, Z et al. Influence of high-concentration hyperbaric oxygen therapy on bone metabolism. Rev Osteoporos Metab Miner [online]. 2020, vol.12, n.1, pp.28-31. Epub June 15, 2020. ISSN 2173-2345. https://dx.doi.org/10.4321/s1889-836x2020000100005.
Objectives:
To learn how high concentration in hyperbaric oxygen therapy (HBO) acts on the expression of genes related to bone metabolism in osteoblast cell lines and human trabecular bone.
Material and methods:
The differential expression of several genes related to bone metabolism (SOST, RUNX2, MMP14, OPG, HIF-1α and SIRT1) in two human osteoblastic cell lines (Saos and Super-Saos) and in human trabecular bone fragments subjected to one, three or five HBO sessions (90 minutes, 100% oxygen; 2.3 atmospheres). In each experiment, a control that did not receive HBO was used.
Results:
We did not find significant differences after HBO in the expression of the genes studied, neither in the cells nor in trabecular bone. Only in the Super-Saos cell line the expression of OPG after 5 sessions of HBO decreased 6 times with respect to that of the control group (2-ΔCt Ct of 72; p=0.01).
Conclusions:
High concentration oxygen in the hyperbaric chamber (HC) does not seem to influence the expression of
genes related to bone metabolism.
Keywords : Oxygen; hyperbaric chamber; bone; genes.
