Introduction:

Outflow tract infection is an important complication in peritoneal dialysis, mainly because it can progress to tunelitis and/or catheter-dependent peritoneal infection that often leads to catheter removal.

Objective:

To analyse the mupirocin application in the management of the healthy exit site and the impact on the infection rate and the percentage of catheter-dependent peritoneal infections.

Material and Method:

Retrospective observational study in a provincial peritoneal dialysis unit. Patients over 18 years of age who underwent peritoneal dialysis at home from 01/01/2019 to 31/12/2021 were included. Variables analysed were: sex, yearly orifice infection rate, responsible germs, catheter-dependent peritoneal infections and appearance of resistance. Data were obtained from the unit’s annual registry.

Results:

Twice-weekly mupirocin application in healthy peritoneal catheter exit site care has decreased the rate of exit site infections from 0.47 episode/patient/year in 2019 to 0.32 in 2020 and 0.16 in 2021, decreasing the percentage of catheter-dependent peritoneal infections from 38% in 2019 to 30% in 2020 and 8% in 2021. No resistance has been observed.

Conclusions:

Mupirocin application in our unit appears to be effective in reducing exit site infections and catheter-dependent peritoneal infections.